You can use the following syntax to merge multiple DataFrames at once in pandas:

import pandas as pd
from functools import reduce

#define list of DataFrames
dfs = [df1, df2, df3]

#merge all DataFrames into one
final_df = reduce(lambda  left,right: pd.merge(left,right,on=['column_name'],
                                            how='outer'), dfs)

The following example shows how to use this syntax in practice:

Example: Merge Multiple DataFrames in Pandas

Suppose we have the following three pandas DataFrames that contain information about basketball players on various teams:

import pandas as pd

#create DataFrames
df1 = pd.DataFrame({'team': ['A', 'B', 'C', 'D'],
                    'points': [18, 22, 19, 14]})

df2 = pd.DataFrame({'team': ['A', 'B', 'C'],
                    'assists': [4, 9, 14]})

df3 = pd.DataFrame({'team': ['C', 'D', 'E', 'F'],
                    'rebounds': [10, 17, 11, 10]})

#view DataFrames
print(df1)

  team  points
0    A      18
1    B      22
2    C      19
3    D      14

print(df2)

  team  assists
0    A        4
1    B        9
2    C       14

print(df3)

  team  rebounds
0    C        10
1    D        17
2    E        11
3    F        10

We can use the following syntax to merge all three DataFrames into one:

from functools import reduce

#define list of DataFrames
dfs = [df1, df2, df3]

#merge all DataFrames into one
final_df = reduce(lambda  left,right: pd.merge(left,right,on=['team'],
                                            how='outer'), dfs)

#view merged DataFrame
print(final_df)

  team  points  assists  rebounds
0    A    18.0      4.0       NaN
1    B    22.0      9.0       NaN
2    C    19.0     14.0      10.0
3    D    14.0      NaN      17.0
4    E     NaN      NaN      11.0
5    F     NaN      NaN      10.0

The final result is one DataFrame that contains information from all three DataFrames.

Notice that NaN values are used to fill in empty cells in the final DataFrame.

To use a value other than NaN to fill in empty cells, we can use the fillna() function: 

from functools import reduce

#define list of DataFrames
dfs = [df1, df2, df3]

#merge all DataFrames into one
final_df = reduce(lambda  left,right: pd.merge(left,right,on=['team'],
                                            how='outer'), dfs).fillna('none')

#view merged DataFrame
print(final_df)

  team points assists rebounds
0    A   18.0     4.0     none
1    B   22.0     9.0     none
2    C   19.0    14.0     10.0
3    D   14.0    none     17.0
4    E   none    none     11.0
5    F   none    none     10.0

Each of the empty cells are now filled with ‘none‘ instead of NaN.

Note: You can find the complete documentation for the merge function in pandas .

Additional Resources

The following tutorials explain how to perform other common operations in pandas:

How to Merge Two Pandas DataFrames on Index

How to Stack Multiple Pandas DataFrames