How can I compute indirect effects with imputed data using Method 2?

How can I compute indirect effects with imputed data using Method 2?

Method 2 for computing indirect effects with imputed data is a statistical approach that involves imputing missing data values and then using a regression-based method to estimate the indirect effects. This method allows researchers to estimate the effects of one variable on another variable through a third variable, even in cases where there are missing data points. By imputing the missing data, the indirect effects can be accurately estimated and potential biases from missing data can be reduced. This formal description outlines the process of using Method 2 to compute indirect effects with imputed data, allowing for more comprehensive and accurate analysis in statistical research.

How can I compute indirect effects with imputed data? (Method 2) | Stata FAQ

NOTE:  Code for this page was tested in Stata 12.

Mediation analysis with multiply imputed data takes a few more step than for
a conventional non-imputed model. We looked at one approach on our page
How can I compute indirect effects with imputed data? (Method 1).
The approach shown on this page is a bit easier to implement and less convoluted.

Let’s begin by looking at the data.

use https://stats.idre.ucla.edu/stat/data/hsbmar, clear

sum science read math female

    Variable |       Obs        Mean    Std. Dev.       Min        Max
-------------+--------------------------------------------------------
     science |       193    51.57513     9.86396         26         74
        read |       185    51.61622    10.19104         28         76
        math |       190    52.17895    9.246168         33         75
      female |       185    .5459459    .4992356          0          1

As you can see from the table above, all of
the variables have a different number of observations. For our example science
is the dependent variable, read is the mediator, math
is the independent variable and female is a covariate.

The method we will use to compute an indirect effect involves the sureg
and nlcom commands to get the product of coefficients.

Let’s go ahead and start our example analysis by performing the multiple imputation.

mi set mlong

mi register imputed read math science female

set seed 485769

mi impute mvn read math science female = write, add(20)

Performing EM optimization:
  observed log likelihood = -1349.5408 at iteration 7

Performing MCMC data augmentation ... 

Multivariate imputation                     Imputations =       20
Multivariate normal regression                    added =       20
Imputed: m=1 through m=20                       updated =        0

Prior: uniform                               Iterations =     2000
                                                burn-in =      100
                                                between =      100

------------------------------------------------------------------
                   |               Observations per m             
                   |----------------------------------------------
          Variable |   Complete   Incomplete   Imputed |     Total
-------------------+-----------------------------------+----------
              read |        185           15        15 |       200
              math |        190           10        10 |       200
           science |        193            7         7 |       200
            female |        185           15        15 |       200
------------------------------------------------------------------
(complete + incomplete = total; imputed is the minimum across m
 of the number of filled-in observations.)

If you try to run mi estimate: sureg (read math female)(science read math female)
you will get an error message that sureg is not officially supported.
However if you add the cmdok option it will run just fine. We also need the
equivalent of the nlcom command.
We can do this by adding effects directly to the mi analyze command.
As shown below, we have added indirect and total effects in parentheses. Each of the effects
is labeled, ind_eff for the indirect effect and tot_eff for the total effect..

mi estimate (ind_eff: [read]_b[math]*[science]_b[read]) ///
   (tot_eff: [read]_b[math]*[science]_b[read] + [science]_b[math]), cmdok: ///
    sureg (read math)(science read math)
    
Multiple-imputation estimates                     Imputations     =         20
                                                  Number of obs   =        200
                                                  Average RVI     =     0.1138
                                                  Largest FMI     =     0.1688
DF adjustment:   Large sample                     DF:     min     =     686.04
                                                          avg     =    1495.76
                                                          max     =    2377.41

------------------------------------------------------------------------------
             |      Coef.   Std. Err.      t    P>|t|     [95% Conf. Interval]
-------------+----------------------------------------------------------------
read         |
        math |   .7038385   .0628724    11.19   0.000     .5805186    .8271584
       _cons |   15.10742   3.321185     4.55   0.000     8.594701    21.62014
-------------+----------------------------------------------------------------
science      |
        read |   .3721145   .0692032     5.38   0.000     .2363619    .5078671
        math |   .4097015   .0780576     5.25   0.000      .256441     .562962
       _cons |   11.00745   3.273573     3.36   0.001     4.585789    17.42911
------------------------------------------------------------------------------

Transformations                                   Average RVI     =     0.1315
                                                  Largest FMI     =     0.1098
DF adjustment:   Large sample                     DF:     min     =    1607.17
                                                          avg     =    1652.73
                                                          max     =    1698.29

      ind_eff: [read]_b[math]*[science]_b[read]
      tot_eff: [read]_b[math]*[science]_b[read] + [science]_b[math]

------------------------------------------------------------------------------
             |      Coef.   Std. Err.      t    P>|t|     [95% Conf. Interval]
-------------+----------------------------------------------------------------
     ind_eff |   .2618675   .0538953     4.86   0.000     .1561551      .36758
     tot_eff |    .671569   .0623058    10.78   0.000     .5493647    .7937733
------------------------------------------------------------------------------

As you can see, the information for the indirect and total effects is added on below the
results
for the sureg command. If we divide the indirect effect by the total effect we
can see the proportion of the total effect that is mediated.

display .26186753/.67156901

.38993391

In this example approximately 39% of the total effect is mediated.

This method of computing indirect effects is superior than
Method 1
because it computes the indirect effects for each imputed dataset than then
combines them using Rubin’s rules rather than computing the indirect effects
once on the final imputed sureg.

Cite this article

stats writer (2024). How can I compute indirect effects with imputed data using Method 2?. PSYCHOLOGICAL SCALES. Retrieved from https://scales.arabpsychology.com/stats/how-can-i-compute-indirect-effects-with-imputed-data-using-method-2/

stats writer. "How can I compute indirect effects with imputed data using Method 2?." PSYCHOLOGICAL SCALES, 1 Jul. 2024, https://scales.arabpsychology.com/stats/how-can-i-compute-indirect-effects-with-imputed-data-using-method-2/.

stats writer. "How can I compute indirect effects with imputed data using Method 2?." PSYCHOLOGICAL SCALES, 2024. https://scales.arabpsychology.com/stats/how-can-i-compute-indirect-effects-with-imputed-data-using-method-2/.

stats writer (2024) 'How can I compute indirect effects with imputed data using Method 2?', PSYCHOLOGICAL SCALES. Available at: https://scales.arabpsychology.com/stats/how-can-i-compute-indirect-effects-with-imputed-data-using-method-2/.

[1] stats writer, "How can I compute indirect effects with imputed data using Method 2?," PSYCHOLOGICAL SCALES, vol. X, no. Y, ص Z-Z, July, 2024.

stats writer. How can I compute indirect effects with imputed data using Method 2?. PSYCHOLOGICAL SCALES. 2024;vol(issue):pages.

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