1| What is Aldolase (ALS)?
Aldolase (ALS) is an enzyme involved in glycolysis, the metabolic pathway used by the body to breakdown glucose for energy production. It is responsible for catalyzing the breakdown of fructose 1,6-bisphosphate into two molecules of glyceraldehyde 3-phosphate.
2| What is the chemical structure of Aldolase (ALS)?
The chemical structure of Aldolase (ALS) is a protein composed of 4 subunits, which are held together by non-covalent bonds. The four subunits consist of two alpha subunits, one beta subunit, and one gamma subunit.
3| What is the molecular weight of Aldolase (ALS)?
The molecular weight of Aldolase (ALS) is approximately 60,000 daltons.
4| What is the function of Aldolase (ALS)?
The function of Aldolase (ALS) is to catalyze the breakdown of fructose 1,6-bisphosphate into two molecules of glyceraldehyde 3-phosphate, which can then be further broken down into pyruvate during glycolysis.
5| Where is Aldolase (ALS) found in the body?
Aldolase (ALS) is found in the cytoplasm of all cells in the body, except for red blood cells.
6| How is Aldolase (ALS) regulated?
Aldolase (ALS) is regulated by phosphorylation and dephosphorylation, which is controlled by hormones and other regulatory molecules.
7| What is the role of Aldolase (ALS) in glycolysis?
Aldolase (ALS) plays an important role in glycolysis by catalyzing the breakdown of fructose 1,6-bisphosphate into two molecules of glyceraldehyde 3-phosphate, which can then be further broken down into pyruvate.
8| What other metabolic pathways is Aldolase (ALS) involved in?
Aldolase (ALS) is also involved in the gluconeogenesis pathway, where it catalyzes the reverse reaction of the breakdown of fructose 1,6-bisphosphate into two molecules of glyceraldehyde 3-phosphate.
9| What are the consequences of a deficiency in Aldolase (ALS)?
A deficiency in Aldolase (ALS) can lead to an impairment in the glycolysis pathway, which can result in a buildup of fructose 1,6-bisphosphate in the body and a decrease in the production of ATP.
10| What diseases are associated with a deficiency in Aldolase (ALS)?
A deficiency in Aldolase (ALS) has been associated with several diseases, including muscle cramps and fatigue, hemolytic anemia, and coronary artery disease. It has also been suggested that it may be associated with Type 2 diabetes.